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Characterization of Topotecan-Mediated Redistribution of DNA Topoisomerase I by Digital Imaging Microscopy
Authors:Randy M Wadkins  Mary K Danks  Lisa Horowitz  Sharyn D Baker
Institution:cDepartment of Clinical Research, Cancer Therapy and Research Center, Institute for Drug Development, 8122 Datapoint, Suite 700, San Antonio, Texas, 78229-3264;aLaboratory of Biophysical Chemistry, Cancer Therapy and Research Center, Institute for Drug Development, 14960 Omicron Drive, San Antonio, Texas, 78245;bDepartment of Molecular Pharmacology, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, Tennessee, 38101
Abstract:
Keywords:microscopy  image analysis  digital  texture  antigen  distribution  immunostaining
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