Phylogenetic study of transcortin using monoclonal antibodies |
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| Authors: | D Faict P De Moor |
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| Affiliation: | 1. Laboratório de Pesquisas Clínicas e Experimentais em Biologia Vascular, Centro Biomédico, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil;2. Departamento de Anestesiologia, Instituto Nacional do Câncer (INCA), Rio de Janeiro, RJ, Brazil;3. Serviço de Anestesiologia, Departamento de Cirurgia Geral, Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil;1. Postdoctoral Scholar, Ecological Restoration Institute, Flagstaff, AZ 86011-5017, USA;2. Senior Lecturer, Environmental Research Institute and Department of Biological Sciences, University of Waikato, Hamilton, New Zealand;3. Associate Professor, School of Environmental and Forest Sciences, University of Washington, Seattle, WA 98195-4115, USA;4. Professor, School of Forestry, Northern Arizona University, Flagstaff, AZ 86011-5018, USA |
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| Abstract: | ![]()
We produced monoclonal antibodies that recognise three distinct epitopes of human transcortin. These epitopes are present on transcortin of humans with normal and altered transcortin levels, as well as on a variant with lower affinity for cortisol. One epitope is present on transcortin of Old World Monkeys and apes, the others are only present on transcortin of apes. The epitopes are not present on transcortin of other species. These results indicate that human transcortin contains a highly evolved and a more conserved part. |
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