Cell division and the stability of cellular populations |
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Authors: | Andrzej Lasota Michael C Mackey |
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Institution: | (1) Institute of Mathematics, Silesian University, ul. Bankowa 14, PL-40-007 Katowice, Poland, PL;(2) Departments of Physiology, Physics and Mathematics, Center for Nonlinear Dynamics in Physiology and Medicine, McGill University, Room 1124, 3655 Drummond Street, Montreal, Quebec, Canada H3G 1Y6. e-mail: mackey@cnd.mcgill.ca, CA |
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Abstract: | This paper couples a general d-dimensional (d arbitrary) model for the intracellular biochemistry of a generic cell with a probabilistic division hypothesis and examines
the consequence of division for stability of cell function and structure. We show rather surprisingly that cell division is
capable of giving rise to a stable population of cells with respect to function and structure even if, in the absence of cell
division, the underlying biochemical dynamics are unstable. In the context of a simple example, our stability condition suggests
that rapid cell proliferation plays a stabilizing role for cellular populations.
Received: 15 January 1996 / Revised version: 31 July 1998 |
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Keywords: | : Cell division Stability Gamma distribution Measure |
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