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Identification and bioinformatics analysis of microRNAs associated with stress and immune response in serum of heat-stressed and normal Holstein cows |
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| Authors: | Yue Zheng Kun-lin Chen Xiao-min Zheng Hui-xia Li Gen-lin Wang |
| Institution: | 1. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China 2. Key Laboratory of Fertility Preservation and Maintenance Ministry of Education, Key Laboratory of Reproduction and Genetic Heredity of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan, 750004, China 3. Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland |
| Abstract: | MicroRNAs (miRNAs) are small single-stranded non-coding RNAs that have an important regulatory function in animal growth and developmental processes. However, the differential expression of miRNA and the role of these miRNAs in heat-stressed Holstein cows are still unknown. In this study, the profile of differentially expressed miRNAs and the target genes analysis in the serum of heat-stressed and normal Holstein cows were investigated by a Solexa deep-sequencing approach and bioinformatics. The data identified 52 differentially expressed miRNAs in 486 known miRNAs which were changed significantly between heat-stressed and normal Holstein cows (fold change >2, P?P? |
| Keywords: | Heat stress Serum MicroRNAs Target genes Cows |
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