Differential expression level of cytokeratin 8 in cells of the bovine nucleus pulposus complicates the search for specific intervertebral disc cell markers |
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| Authors: | Audrey Gilson Mathias Dreger Jill PG Urban |
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| Institution: | (1) Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, UK;(2) Caprotec Bioanalytics GmbH, Volmerstrasse 5, Berlin, 12489, Germany |
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| Abstract: | Introduction Development of cell therapies for repairing the intervertebral disc is limited by the lack of a source of healthy human disc
cells. Stem cells, particularly mesenchymal stem cells, are seen as a potential source but differentiation strategies are
limited by the lack of specific markers that can distinguish disc cells from articular chondrocytes. |
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