Sensing the hybrid—a novel PAMP for TLR9 |
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| Authors: | Søren B Jensen Søren R Paludan |
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| Institution: | 1. Department of Biomedicine, Aarhus University, Aarhus, Denmark;2. Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, Denmark |
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| Abstract: | The host immune response is initiated by pattern recognition receptors (PRR) when triggered by specific ligands known as pathogen‐associated molecular patterns (PAMP). Toll‐like receptor 9 is highly expressed in plasmacytoid dendritic cells and is well described as a PRR for CpG DNA which induce the production of cytokines and type I interferons. In this issue of The EMBO Journal, Rigby et al identify RNA–DNA hybrids as a novel PAMP specifically recognized by TLR9 in dendritic cells. |
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