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Kinetics of three substrate enzyme systems. Treatment of partially random mechanisms using equilibrium assumptions
Authors:F B Rudolph  H J Fromm
Institution:Department of Biochemistry, Rice University, Houston, Texas 77001, U.S.A.;Department of Biochemistry and Biophysics, Iowa State University, Ames, Iowa 50010, U.S.A.
Abstract:There are three partially random kinetic mechanisms which may be visualized for enzymes that catalyze reactions involving three substrates. The steady-state rate equation for these mechanisms can be reduced to the form derived by assuming equilibrium kinetics from consideration of inequality relationships among rate constants alone. The validity of these assumptions and of the resulting rate laws is considered.
Keywords:Person to whom correspondence should be addressed  
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