Synthesis and immunological evaluation of self-adjuvanting glycolipopeptide vaccine candidates |
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Authors: | Fujita Yoshio Abdel-Aal Abu-Baker M Wimmer Norbert Batzloff Michael R Good Michael F Toth Istvan |
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Institution: | School of Molecular and Microbial Sciences (SMMS), The University of Queensland, St. Lucia 4072, Qld, Australia. |
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Abstract: | Synthesis of four glycolipids with different number of lauroyl groups on glucose or cellobiose as scaffolds is described. Their immunological evaluations either admixed with or covalently linked to J8, a peptide antigen derived from the C-terminus of the antiphagocytic M-protein of group A streptococcus, are also investigated. Administration of mixtures of J8 and glycolipids to B10BR (H-2(k)) mice induced low-levels of J8-specific IgG antibodies. While glycolipopeptides, in which J8 was covalently linked to the synthetic glycolipids, demonstrated high-levels of antibody titers comparable with the co-administration of these glycolipopeptides with complete Freund's adjuvant, suggesting clearly the strong potency of the synthesized glycolipids as self-adjuvanting moieties. |
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