Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion |
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| Authors: | Rho Seung-Sik Choi Hyun-Jung Min Jeong-Ki Lee Heon-Woo Park Hongryeol Park Hyojin Kim Young-Myeong Kwon Young-Guen |
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| Affiliation: | aDepartment of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea;bTherapeutic Antibody Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea;cDepartment of Molecular and Cellular Biochemistry, Kangwon National University, Chunchon, Republic of Korea |
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| Abstract: | Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell–cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell–cell adhesion and angiogenesis. |
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| Keywords: | Abbreviation: Clec14a C-type lectin domain family 14 member a |
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