Effects of estradiol and FSH on maturation of the testis in the hypogonadal (hpg) mouse |
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| Authors: | Helen Baines Margaret O Nwagwu Graham R Hastie Roman A Wiles Terry M Mayhew Francis JP Ebling |
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| Affiliation: | (1) School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK |
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| Abstract: | Background The hypogonadal (hpg) mouse is widely used as an animal model with which to investigate the endocrine regulation of spermatogenesis. Chronic treatment of these GnRH-deficient mice with estradiol is known to induce testicular maturation and restore qualitatively normal spermatogenesis. The aim of the current studies was to investigate whether these effects of estradiol are direct effects in the testis, or indirect actions via paradoxical stimulation of FSH secretion from the pituitary gland. |
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