脂类对盐酸,乙醇致大鼠胃粘膜损伤的保护作用

本实验用Ｓｐｒａｇｕｅ－Ｄａｗｌｅｙ大鼠胃内给予二山酰卵磷脂与三棕榈酰甘油酯１：４（ｗ／ｗ）混合物（每只鼠１ｍｌ，含５ｍｇ混合物）保护０．６ｍｏｌ／Ｌ盐酸致胃粘膜损伤，使溃疡指数及溃疡面积与胃总面积比分别降低了７６．２７％及８０．２４％（Ｐ＜０．０１），胃粘膜表面疏水性及跨膜电位值显著增加（Ｐ＜０．０５）。该混合物对无水乙醇所致胃粘膜损伤无明显保护作用。提示脂类对盐酸致胃粘膜损伤的保护作用与其维持表面疏水性有关，但这种疏水表面对不同致损伤因子的作用是有差异的。

EFFECTS 0F LIPIDS 0N ACID AND ETHANOL INDUCED GASTRIC MUCOSA INJURY IN RATS

It has been shown that intragastric administration of a suspension consisting of dibehenoylphosphotidylcholine and tripalmitin at a ratio of 1:4(w/w)(5 mg per rat) protected rat gastric mucosa from injury caused by 0.6 mol/ L HCl, resulting in the reduction of ulcer in-dex and the ratio of ulcer area to total mucosal area by 76.27% and 80.24% respectively.Thelipid mixture also significantly increased the surface hydrophobicity of and potential differenceacross the gastric mucosa. However,no protection against absolute ethanol challenge was ob-served.The results suggest that the protective effect of lipids on acid injury has relevance to main-tenance of surface hydrophobicity which rendered different barrier functions to different ulcerat-ing agents.