Food intake in rhesus monkeys following central administration of orexins |
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Authors: | Ramsey Jon J Kemnitz Joseph W Newton Wendy Hagopian Kevork Patterson Terrell A Swick Andrew G |
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Institution: | Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. jjramsey@ucdavis.edu |
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Abstract: | Orexin A has been reported to stimulate food intake in rats while orexin B does not. The purpose of this study was to determine the role of orexin A or orexin B administration on food intake in adult, male rhesus monkeys. Food intake was measured at 2 and 8 h after the morning feeding following central injections of vehicle, orexin A (10, or 20 microg) or orexin B (10, 30, or 100 microg). When compared to vehicle injections, the 10 and 20 microg doses of orexin A decreased food intake at 2 h post-dose by 45% and 64%, respectively. Eight-hour food intake was decreased at only the 20 microg orexin A dose. Orexin B at all doses and time points did not alter food intake when compared to vehicle. These results indicate that orexin A exhibits anorectic activity while orexin B does not affect food intake in the rhesus monkey. |
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