Synthesis and biological activity of 1beta-methyl-2-[5'-isoxazoloethenylpyrrolidin-3'-ylthio]carbapenems |
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| Authors: | Kim D J Seo K J Lee K S Shin K J Yoo K H Kim D C Park S W |
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| Affiliation: | Life Sciences Division, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea. djk2991@kist.re.kr |
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| Abstract: | A new series of 1beta-methylcarbapenems 1a-i bearing isoxazoloethenyl groups on the pyrrolidine ring has been prepared and evaluated for in vitro antibacterial activity and stability to DHP-I. Most compounds showed excellent antibacterial activity and high stability to DHP-I superior to that of meropenem. Of these new carbapenems, 1a,b,h exhibited the best combination of antibacterial activity and DHP-I stability. |
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