GLP-1 expression in von Ebner's gland of diabetic rats |
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| Authors: | Xiao-hong Feng Li-hong Zhou Dong Wang Xiao Yuan |
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| Institution: | 1. Department of Endocrinology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China;2. Department of Endocrinology, The First Clinical Hospital of Harbin Medical University, Harbin 150001, China |
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| Abstract: | GLP-1, a peptidergic endocrine hormone, which associate with appetite control, glucose homeostasis and satiety. It might play an important role in the gustatory system. We tried to investigate the expression of GLP-1 in von Ebner's gland of diabetic and control rats, and the ultrastructure changes on von Ebner's gland of diabetes rats. GLP-1 expression in von Ebner's gland was evaluated by immunohistochemistry. The number of GLP-1 positive cells in diabetic rat von Ebner's gland was significantly higher than that in normal controls. Electron micrographs showed that a series of pathologic changes in von Ebner's gland of diabetes rats. The results suggest that GLP-1 have some effects within the gustatory systems, and elevated von Ebner's gland GLP-1 expression may be one cause of diabetic taste impairment. |
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| Keywords: | Glucagon-like peptide-1 von Ebner's gland Diabetes Rats |
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