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Effect of insulin-like growth factor-I (IGF-I) on femoral bone modeling in growing mice. |
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| Authors: | Toshitsugu Kawata Chiyoko Tokimasa Tadashi Fujita Masato Kaku Keisuke Tsutsui Shinya Kohno Akira Matsuki Kaoru Tenjo Junji Ohtani Masahide Motokawa Takashi Kobayakawa Mao Shigekawa Kazuo Tanne |
| Affiliation: | Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. |
| Abstract: | The time-dependent effects of daily dosing of IGF-I (1.21 mg/g) on the linear growth of the femur were investigated in mice. The femoral length and volume and the number of osteoclasts were significantly greater after IGF-I injection as compared to the non-injected control, suggesting that the IGF-I imbalance might cause a quick turnover cycle of the bone resulting in the altered femoral modeling. |
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