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Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation |
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| Authors: | Witherington Jason Abberley Lee Briggs Michael A Collis Katharine Dean David K Gaiba Alessandra King N Paul Kraus Helmut Shuker Nicola Steadman Jon G A Takle Andrew K Sanger Gareth Wadsworth Graham Butler Sharon McKay Fiona Muir Alison Winborn Kim Heightman Tom D |
| Affiliation: | Department of Medicinal Chemistry & DMPK, Neurology & GI Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Jason_Witherington@GSK.com |
| Abstract: | A series of small molecule orally bioavailable ghrelin receptor agonists have been identified through systematic optimisation of a high throughput screening hit. |
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