Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo) |
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Authors: | Cecilie Totland Geir Bredholt Mette Haugen Bjørn Ivar Haukanes Christian A Vedeler |
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Institution: | (1) Department of Neurology, Haukeland University Hospital, Bergen, Norway;(2) Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway;(3) Department of Clinical Medicine, University of Bergen, Bergen, Norway |
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Abstract: | Patients with cancer may develop paraneoplastic neurological syndromes (PNS) in which onconeural antibodies are important
diagnostic findings. As the functional role of onconeural antibodies is largely unknown, insight gained by identifying associated
antibodies may help to clarify the pathogenesis of the PNS. In this study, we identified patients with Yo antibodies who also
had antibodies to an uncharacterized protein called coiled-coil domain-containing protein 104 (CCDC104). We found a significant
association between CCDC104 and Yo antibodies (4 of 38, 10.5%), but not other onconeural antibodies (0 of 158) (P = 0.007, Fisher’s exact test). The prevalence of CCDC104 antibodies was approximately similar in patients with cancer (8
of 756, 1.1%) and in healthy blood donors (2 of 300, 0.7%). CCDC104 antibodies were not associated with PNS, as this was found
in only two of the ten CCDC104-positive patients. The CCDC104 protein, whose function is unknown, is expressed in various
human tissues, including the brain, and is localized mainly to the nucleus, but is also found in the cytoplasm. The association
between Yo and CCDC104 antibodies may indicate functional similarities. |
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