| 糖皮质激素快速抑制牛蛙椎旁神经节B细胞快兴奋性突触后电位 |
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| 引用本文： | Ma B,Yi BD,Xing BR. 糖皮质激素快速抑制牛蛙椎旁神经节B细胞快兴奋性突触后电位[J]. 生理学报, 1998, 50(6): 679-682 |
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| 作者姓名： | Ma B Yi BD Xing BR |
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| 作者单位： | 1. 第二军医大学生理教研室,上海,200433
2. 贵阳医学院生理教研室,贵阳,550004 |
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| 基金项目： | 军队医药项目,96Z035, |
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| 摘 要： | 用单个方波电刺激牛蛙离体椎旁经节前纤维,细胞内记录节后Ｂ细胞快兴奋性突后电位,观察糖皮质激素对Ｂ细胞ｆ－ＥＰＳＰ的快速抑制作用。结果发现,ＧＣ灌注３ｍｉｎ,。Ｂ细胞ｆ－ＥＰＳＰ的幅值减小,撤除ＧＣ后,ＥＰＳＰ的幅值恢复到对照水平。作用具有剂量信赖性。
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| 关 键 词： | 糖皮质激素 椎旁神经节 f－EPSP |
| 修稿时间： | 1997-10-05 |
Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia |
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| Ma B,Yi B D,Xing B R. Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia[J]. Acta Physiologica Sinica, 1998, 50(6): 679-682 |
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| Authors: | Ma B Yi B D Xing B R |
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| Affiliation: | Department of Physiology, Second Military Medical University, Shanghai 200433. |
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| Abstract: | In the present study, the rapid effect of hydrocortisone 21-hemisuccinate (F-suc) on the amplitude of f-EPSP of B cells in isolated bullfrog sympathetic ganglia was examined with the use of intracellular recording technique. It was found that the amplitude of f-EPSP of B cells was decreased by F-suc, with a latency less than 3 min after the beginning of perfusion of F-suc. The inhibition of F-suc was concentration-dependent and could be blocked by the antagonist of intracellular glucocorticoid receptor RU38486, but not by the protein synthesis inhibitor actidione. These findings suggest that the inhibition of f-EPSP of B cells by F-suc is probably mediated through a nongenomic mechanism. |
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| Keywords: | glucocorticoid paravertebral ganglia excitatory postsynaptic potential rapid effect |
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