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Increase in placental 15-hydroxy-prostaglandin dehydrogenase in the first half of human pregnancy
Authors:M.J.N.C. Keirse   J.J.H.M. Erwich  G. Klok
Affiliation:Department of Obstetrics and Gynecology, University of Leiden Medical Center, Leiden, The Netherlands
Abstract:NAD-dependent 15-hydroxy-prostaglandin dehydrogenase (PGDH) activity was measured in homogenates of 25 human placentae obtained between 7 and 17 weeks of gestation. PGDH activity, expressed in nanomoles PGF metabolized per min, ranged from 0.2 to 5.4 nmoles per mg placental protein and from 1.5 to 80 nmoles per g wet weight. PGDH activity per mg protein and per g weight increased significantly in function of gestational age (p<0.001). Between 7–8 weeks' gestation and 15–16 weeks mean values increased tenfold from 0.4 to 3.0 nmoles per mg protein and from 2.7 to 36.6 nmoles per g wet weight. Per unit of weight these early placentae contained less PGDH activity than term controls, but this related mainly to their high water content. Per mg placental protein PGDH activities already equalled values found at term before the end of the first trimester. The data indicate that the development of terminal villi and the migration of trophoblast into the maternal spiral arteries is associated with a substantial increase in the placental capacity for prostaglandin metabolism.
Keywords:Reprint requests to M.J.N.C. Keirse   Department of Obstetrics & Gynecology   Leiden University Medical Centre   Rijnsburgerweg 10   2333 AA Leiden   The Netherlands
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