DNA sequence of the coding region of the HLA-B44 gene |
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| Authors: | Andreas H Kottmann Gerhard H A Seemann H Detlef Guessow Marleen H Roos |
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| Institution: | (1) Division of Cell Biology, The Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands;(2) Present address: Max-Planck-Institut für Immunobiologie, Freiburg, Germany |
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| Abstract: | An HLA-B44 cDNA clone was identified in a cDNA library constructed from an HLA-B44 homozygous cell line. The DNA sequence was determined and was found to contain the complete coding sequence but for (probably) the three N-terminal codons. Comparisons of the derived amino acid sequence with other HLA-A and -B locus amino acid sequences revealed four HLA-B44-specific substitutions including a new polymorphic site. Regions of strong sequence conservation for HLA-B-locus products were found at the nucleotide and amino acid levels. |
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