| 沼泽红假单胞菌2c菌株的安全性评价 |
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| 引用本文： | 方立超,王斌,张锦亮,刘瑞兰,袁静,魏泓.沼泽红假单胞菌2c菌株的安全性评价[J].氨基酸和生物资源,2005,27(2):52-54,74. |
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| 作者姓名： | 方立超 王斌 张锦亮 刘瑞兰 袁静 魏泓 |
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| 作者单位： | 第三军医大学基础部实验动物学教研室,重庆,400038;第三军医大学基础部实验动物学教研室,重庆,400038;第三军医大学基础部实验动物学教研室,重庆,400038;第三军医大学基础部实验动物学教研室,重庆,400038;第三军医大学基础部实验动物学教研室,重庆,400038;第三军医大学基础部实验动物学教研室,重庆,400038 |
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| 摘 要： | 本实验旨在对1株沼泽红假单胞菌Rhodopseudomonaspalustris2c菌株(2c)作为益生菌株的安全性进行系统研究。结果表明,2c菌株体外对多数抗生素敏感;在体内不具有急性毒性,不会在血液中产生内毒素,在宿主体内自身不会易位,也不会造成其它肠道细菌易位,对肝肾功能无不良影响,对回肠黏膜及其细胞形态和结构无不良影响。2c菌株具备益生菌安全特性,值得进一步研究。
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| 关 键 词： | 沼泽红假单胞菌 安全性 细菌易位 内毒素 |
| 文章编号： | 1006-8376(2005)02-0052-03 |
Safety Evaluation of A Potential Probiotic Rhodopseudomonas palustris 2c |
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| FANG Li-chao,WANG Bin,ZHANG Jing-liang,LIU Rui-lan,YUAN Jing,WEI Hong.Safety Evaluation of A Potential Probiotic Rhodopseudomonas palustris 2c[J].Amino Acids & Biotic Resources,2005,27(2):52-54,74. |
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| Authors: | FANG Li-chao WANG Bin ZHANG Jing-liang LIU Rui-lan YUAN Jing WEI Hong |
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| Abstract: | The safety of a potential probiotic Rhodopseudomonas palustris 2c was studied systematically. Results showed:2c was of susceptibility to most of the antibiotics examed in vitro; 2c had not acute toxicity when it was orally administered by mice with dose of 5×1011CFU/Kg bt. 2c did not produce endogenous toxin in plasma; it neither translocated itself, nor caused other bacteria in intestinal tract translocate ;it had no adverse effects on the function of liver and kidney, when 2c was orally administered by rats. |
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| Keywords: | Rhodopseudomonas palustris safety bacterium translocation endogenous toxin |
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