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Algal oxidation of aromatic hydrocarbons: formation of 1-naphthol from naphthalene by Agmenellum quadruplicatum, strain PR-6. |
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| Authors: | C E Cerniglia D T Gibson C Van Baalen |
| Affiliation: | Gesellschaft f. Strahlen- und Umweltforschung, Abteilung für Toxikologie, Ingolstädter Landstr. 1, D-8042 Neuherberg/München, G.F.R. |
| Abstract: | Hydroxyurea induces repair replication in human lymphoblastoid NC37 BaEV cells during incubation with liver microsomes and NADPH. Catalase reduces hydroxyurea-induced repair by more than 95%, suggesting that hydrogen peroxide derived from hydroxyurea in the presence of the metabolic activation system is involved in the DNA damage. |
| Keywords: | HU hydroxyurea G6P glucose-6-phosphate G6P-DH glucose-6-phosphate dehydrogenase FUdR 5-fluorodeoxyuridine BUdR 5-bromodeoxyuridine TdR thymidine PBS phosphate buffered saline TCA trichloroacetic acid MNNG N-methyl-N-nitro-N-nitrosoguanidine SKF 525-A 2-dimethylaminoethyl-2,2-diphenyl valerate |
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