Search for potential Angiotensin Converting Enzyme (ACE)-inhibitors from plants |
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| Authors: | M.A. Lacaille-Dubois U. Franck H. Wagner |
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| Affiliation: | Laboratoire de Pharmacognosie, Unité de Molecules d'Intérêt Biologique, Faculté de Pharmacie, Université de Bourgogne, Dijon, France. malacd@u-bourgogne.fr |
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| Abstract: | MeOH extracts, fractions and pure substances from Musanga cecropioides, Cecropia species and Crataegus oxyacantha /C. monogyna were screened by using an in vitro bio-assay based on the inhibition of Angiotensin Converting Enzyme (ACE), as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. Phenolic acids showed no significant ACE-inhibition whereas flavonoids and proanthocyanidins demonstrated inhibitory activity at 0.33 mg/ml using this test system. |
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| Keywords: | Musanga cecropioides Cecropia species and Crataegus oxyacantha/C. monogyna angiotensin converting enzyme ACE hypotensive agents flavonoids procyanidins |
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