Protection of iron-catalysed the radical damage to DNA and lipids by copper (II) bleomycin |
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Authors: | J M Gutteridge F Xiao Change |
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Institution: | Division of Antibiotics National Institute for Biological Standards and Control Holly Hill, Hampstead, London NW3 6RB, UK |
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Abstract: | The ability of Copper(II)-bleomycin to inhibit oxygen-free-radical damage to biomolecules has been assessed. This copper complex showed inhibitory properties towards iron-catalysed damage to phospholipid membranes and cell-free DNA. It was also able to prevent superoxide-dependent reduction of nitroblue tetrazolium (NBT). Unlike iron, copper-bleomycin does not damage DNA . This may result from a site-specific dismutation of superoxide radicals on the DNA molecule. |
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