Application of DNA methyltransferases in targeted DNA methylation |
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Authors: | Albert Jeltsch Renata Z Jurkowska Tomasz P Jurkowski Kirsten Liebert Philipp Rathert Martina Schlickenrieder |
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Institution: | (1) Institut für Bioprozess- und Analysenmesstechnik e.V., Rosenhof, 37308 Heilbad Heiligenstadt, Germany |
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Abstract: | Taxol is a valuable plant-derived drug showing activity against various cancer types. Worldwide efforts had been made to overcome
the supply problem, because the supply by isolation from the bark of the slow-growing yew trees is limited. Plant cell cultures
as well as chemical and biotechnological semisynthesis are processes, which are intensively investigated for the production
of taxanes paclitaxel (Taxol) and docetaxel (Taxotere) in the last few years. This article provides a comparison of the current
research on taxane biosynthesis and production in yew cell cultures. |
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Keywords: | DNA methyltransferase Epigenetics Enzyme design DamID |
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