自体疗法对组织愈合和再生的促进作用的研究进展

组织工程和再生医学是基础研究和转化医学的热点,传统的组织工程和再生医学方法依赖体外构建组织、外源性干细胞移植至靶部位等方法,尽管这些方法在体外细胞研究、动物研究中证实可以达到组织修复和再生等作用,然而,临床实践尚存在一定问题,无法有效转化。基于干细胞、发育生物学、免疫学、生物工程和材料科学的最新进展,新一代体内再生的医学疗法,即自体疗法得以应用。自体疗法是一种基于优化内源性组织反应,利用干细胞和内源性组织微环境,促进组织愈合和再生的策略。本文将对自体疗法的概念、作用、微环境及优化自体疗法途径做一综述。

Advances in autotherapies on enhancing endogenous healing and regeneration

Tissue engineering and regenerative medicine are hot topics in basic research and translational medicine.Traditional tissue engineering and regenerative medicine approaches rely on the generation of tissue constructs in vitro or ex vivo stem cell transplantation to target sites.Although these methods have been shown to achieve tissue repairmen and regeneration in vitro and in vivo,few such therapies have succeeded in clinical practice.Recent advances in the stem cell and developmental biology,immunology,bioengineering,and material sciences promote us to develop a new generation of in vivo regenerative medicine therapies:autotherapies.Autotherapies are strategies based on optimizing endogenous tissue responses and capitalizing on manipulation of stem cell niches and endogenous tissue microenvironments to enhance tissue healing and regeneration.This article reviews the concept,role,microenvironment of autotherapy and the strategy onoptimizing autotherapies.