| 微小RNAs在肝癌中的作用机制及相关应用研究进展 |
| |
| 引用本文： | 马晓琨,夏伟.微小RNAs在肝癌中的作用机制及相关应用研究进展[J].中华细胞与干细胞杂志(电子版),2020,10(1):52-56. |
| |
| 作者姓名： | 马晓琨 夏伟 |
| |
| 作者单位： | 1. 200137 上海中医药大学附属第七人民医院核医学科 |
| |
| 基金项目： | 国家自然科学基金(81873178);上海市浦东新区卫生和计划生育委员会重点学科主攻课题(PWZxk2017-06);上海市高级中西医结合人才培养项目(ZY(2018-2020)-RCPY-2012);浦东新区科技发展基金(PKJ2017-Y14)。 |
| |
| 摘 要： | 微小RNAs(miRNAs)是一类内源性小型非编码RNA,可通过调控靶基因表达参与大多数生物学过程。近年来,miRNAs在肝癌发生发展进程中相关作用机制的研究逐渐深入,miRNAs作为其中关键调控因子和主要参与者,已成为肝癌早期诊断、靶向治疗和预后评估中的一个关键靶标。本文着重强调miRNAs在肝癌发生发展、多重耐药性中的作用以及作为肝癌潜在治疗靶点的价值,并就miRNAs在肝癌中的功能、分子作用通路以及应用三方面的相关研究进展进行综述。
|
| 关 键 词： | 微小RNAs 肝癌 信号通路 多重耐药 诊断治疗 |
| 收稿时间： | 2019-07-24 |
Advances of the mechanism and application of microRNAs in hepatocellular carcinoma |
| |
| Authors: | Ma Xiaokun Xia Wei |
| |
| Institution: | 1. Department of Nuclear Medicine, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China |
| |
| Abstract: | MicroRNAs(miRNAs)represent a class of small-sized endogenous non-coding RNA involved in most biological processes by imposing regulation on the expression of target genes.In recent years,the understanding as to the mechanisms of miRNAs in the hepatocellular carcinoma(HCC)have been improved on a continued basis.As a significant regulator and major participant in the process,miRNAs have been regarded as a crucial target in early diagnosis,target treatment and the prognosis evaluation of HCC.In this paper,our emphasis is placed on the role that miRNAs play in the developmental process,the multi-drug resistance of HCC and the value of miRNAs as the potential therapeutic target for HCC,and a summary is made of the progress made in research conducted into the function,molecular pathways and application of miRNAs in HCC. |
| |
| Keywords: | MicroRNAs Hepatocellular carcinoma Signal pathway Multidrug resistance Diagnosis and treatment |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《中华细胞与干细胞杂志(电子版)》浏览原始摘要信息 |
| 点击此处可从《中华细胞与干细胞杂志(电子版)》下载免费的PDF全文 |
