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Determination by high-performance liquid chromatography of hydroxyurea in human plasma |
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| Authors: | J. Havard |
| Affiliation: | Department of Biochemistry, Royal North Shore Hospital, Pacific Highway, St. Leonards, N.S.W. 2065 Australia Department of Clinical Oncology, Royal Prince Alfred Hospital, Camperdown, N.S.W. 2050 Australia Department of Biochemistry, Royal North Shore Hospital, Pacific Highway, St. Leonards, N.S.W. 2065 Australia |
| Abstract: | An assay using reversed-phase high-performance liquid chromatography with electrochemical detection was developed to measure hydroxyurea in plasma at concentrations suitable for pharmacokinetic studies. The sample preparation is simple, the analysis rapid and assays can be batched. The between-run precision is excellent (coefficient of VARIATION = 2.8–4.5%) and the limit of detection is 0.02 mmol/l. Preliminary studies have shown that the method is suitable for pharmacokinetic studies. |
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