The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19 |
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| Authors: | C Julier D Weil P Couillin J C Côté Cong Van Nguyen C Foubert A Boué J P Thirion J C Kaplan C Junien |
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| Institution: | (1) Institut de Pathologie et Biologie cellulaires et Moléculaires, INSERM U. 129, 24, rue du Fbg St Jacques, F-75674 Paris Cedex 14, France;(2) Unité de Recherches de Génétique médicale, INSERM U. 12, 149, rue de Sèvres, F-75743 Paris Cedex 15, France;(3) Groupe de Recherches de Biologie prénatale, INSERM U. 73, Château de Longchamp, Bois de Boulogne, F-75016 Paris, France;(4) Département de Microbiologie-Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, J1H5N4 Québec, Canada |
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| Abstract: | Summary We used a cloned human cDNA probe homologous to the placenta chorionic gonadotropin  subunit (CGB) and to the pituitary luteinizing hormone subunit (LHB) and Southern blotting techniques to analyse DNA from a series of rodent x human somatic cell hybrids for the presence of specific gonadotropin subunit related sequences. Our results provide evidence for the assignment and linkage of the eight genes (or pseudogenes) coding for the subunit of these glycoprotein hormones to chromosome 19. Moreover, we observed a strict concordance between the permissivity of mouse x man hybrid cells to enteroviruses (which is linked to the presence of specific cell receptors encoded by human chromosome 19) and the presence of CGB and LHB related sequences, thus confirming the localization of the structural genes for the subunits on chromosome 19.This work was supported in part by INSERM grants CRL 81 1041 and by MRC grant MT 4860 |
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