Sequencing and comparative analysis of fugu protocadherin clusters reveal diversity of protocadherin genes among teleosts |
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Authors: | Wei-Ping Yu Kenneth Yew Vikneswari Rajasegaran Byrappa Venkatesh |
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Institution: | (1) Gene Regulation Laboratory, National Neuroscience Institute, 11 Jalan Tan Tock Seng, 308433, Singapore;(2) Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore |
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Abstract: | Background The synaptic cell adhesion molecules, protocadherins, are a vertebrate innovation that accompanied the emergence of the neural
tube and the elaborate central nervous system. In mammals, the protocadherins are encoded by three closely-linked clusters
(α, β and γ) of tandem genes and are hypothesized to provide a molecular code for specifying the remarkably-diverse neural
connections in the central nervous system. Like mammals, the coelacanth, a lobe-finned fish, contains a single protocadherin
locus, also arranged into α, β and γ clusters. Zebrafish, however, possesses two protocadherin loci that contain more than
twice the number of genes as the coelacanth, but arranged only into α and γ clusters. To gain further insight into the evolutionary
history of protocadherin clusters, we have sequenced and analyzed protocadherin clusters from the compact genome of the pufferfish,
Fugu rubripes. |
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Keywords: | |
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