The promotive effect of interleukin 4 with interleukin 2 in the proliferation of tumor-infiltrating lymphocytes from patients with malignant tumor |
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Authors: | Takuya Tsunoda Hiroshi Tanimura Hiroki Yamaue Makoto Iwahashi Masaji Tani Mikoko Tamai Kazuo Arii Kohei Noguchi |
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Institution: | (1) Department of Gastroenterological Surgery, Wakayama Medical College, 27-Shichibancho, 640 Wakayama, Japan |
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Abstract: | In adoptive immunotherapy, the number of effector cells is one of the major factors relating to the therapeutic efficacy. We demonstrated that tumor-infiltrating lymphocytes (TILs) were stimulated to proliferate by incubation with interleukin 2 (IL-2) plus interleukin 4 (IL-4). TILs cultured with IL-2 plus IL-4 increased 3.1-fold more than TILs cultured with IL-2 alone. However, IL-4 did not alter the cytotoxic activity of TILs against autologous tumor cells and established tumor cell lines. It is suggested that IL-2 receptor is related to the mechanism of the proliferation of activated TILs cultured by combination with IL-2 and IL-4. Thus, the combination of IL-2 and IL-4 may increase the efficacy of adoptive immunotherapy using activated TILs. |
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Keywords: | adoptive immunotherapy interleukin 2 interleukin 4 interleukin 2 receptor tumor-infiltrating lymphocytes |
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