Synergistic effect of estrogen and androgen on induction of uterine thymidine kinase activities in immature rats |
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| Authors: | Noriko Yamada Shinobu Sakamoto Rhohei Okamoto |
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| Institution: | Department of Endocrinology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113 Japan |
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| Abstract: | Estrdiol-17β induced a significant increase in the uterine thymidine kinase activity with a characteristic isozyme pattern 30 h after injection into immature rats. Testosterone propionate also revealed a similar increase. Following combined injection of estradiol-17β and testosterone propionate, the overall and separate isozyme activities of thymidine kinase increased to nearly the total amount of those when each hormone was injected separately. |
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| Keywords: | Enzyme induction Estrogen Androgen Thymidine kinase (Rat uterus) |
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