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HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design
Authors:Christine A. Bricault  Karina Yusim  Michael S. Seaman  Hyejin Yoon  James Theiler  Elena E. Giorgi  Kshitij Wagh  Maxwell Theiler  Peter Hraber  Jennifer P. Macke  Edward F. Kreider  Gerald H. Learn  Beatrice H. Hahn  Johannes F. Scheid  James M. Kovacs  Jennifer L. Shields  Christy L. Lavine  Fadi Ghantous  Bette Korber
Affiliation:1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;2. Los Alamos National Laboratory, Los Alamos, NM 87545, USA;3. New Mexico Consortium, Los Alamos, NM 87545, USA;4. Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;5. Massachusetts General Hospital, Boston, MA 02114, USA;6. Harvard Medical School, Boston, MA 02114, USA;7. Division of Molecular Medicine, Children’s Hospital, Boston, MA 02115, USA;8. Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;9. Departments of Chemistry and Biochemistry, University of Colorado, Colorado Springs, CO 80918, USA;10. Department of Medicine and CFAR, University of Alabama at Birmingham, Birmingham, AL 35294, USA;11. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Boston, MA 02114, USA;12. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA;13. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA;14. Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA;15. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA;16. Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
Abstract:
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  • Keywords:HIV-1  broadly neutralizing antibodies  signature analysis  machine learning  vaccine design  V2-apex antibodies  hypervariable regions
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