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HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design
Authors:Christine A Bricault  Karina Yusim  Michael S Seaman  Hyejin Yoon  James Theiler  Elena E Giorgi  Kshitij Wagh  Maxwell Theiler  Peter Hraber  Jennifer P Macke  Edward F Kreider  Gerald H Learn  Beatrice H Hahn  Johannes F Scheid  James M Kovacs  Jennifer L Shields  Christy L Lavine  Fadi Ghantous  Bette Korber
Institution:1. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA;2. Los Alamos National Laboratory, Los Alamos, NM 87545, USA;3. New Mexico Consortium, Los Alamos, NM 87545, USA;4. Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;5. Massachusetts General Hospital, Boston, MA 02114, USA;6. Harvard Medical School, Boston, MA 02114, USA;7. Division of Molecular Medicine, Children’s Hospital, Boston, MA 02115, USA;8. Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA;9. Departments of Chemistry and Biochemistry, University of Colorado, Colorado Springs, CO 80918, USA;10. Department of Medicine and CFAR, University of Alabama at Birmingham, Birmingham, AL 35294, USA;11. Ragon Institute of Massachusetts General Hospital, MIT, and Harvard, Boston, MA 02114, USA;12. Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA;13. Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA;14. Department of Immunology, Duke University School of Medicine, Durham, NC 27710, USA;15. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20814, USA;16. Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
Abstract:
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  • Keywords:HIV-1  broadly neutralizing antibodies  signature analysis  machine learning  vaccine design  V2-apex antibodies  hypervariable regions
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