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Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope
Authors:Xishan Lu  Haixia Xiao  Shihua Li  Xuefei Pang  Jian Song  Sheng Liu  Huijun Cheng  Yan Li  Xiangxi Wang  Chaobin Huang  Tianling Guo  Jan ter Meulen  Stephane Daffis  Jinghua Yan  Lianpan Dai  Zihe Rao  Hans-Dieter Klenk  Jianxun Qi  George F Gao
Institution:1. Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;2. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;3. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China;4. National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;5. Institut für Virologie, Philipps-Universität, Robert-Koch-Strasse 17, Marburg 35037, Germany;6. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;7. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Abstract:
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  • Keywords:yellow fever virus  neutralizing monoclonal antibody  envelope protein  flavivirus  crystal structure  epitope  prefusion  postfusion
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