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Reduction of ricin and other plant toxins by thiol:protein disulfide oxidoreductases |
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| Authors: | Luigi Barbieri Maria Giulia Battelli Fiorenzo Stirpe |
| Institution: | Istituto di Patologia Generale dell''Università di Bologna, I-40126 Bologna, Italy |
| Abstract: | The inhibitory effect of ricin, abrin, and modeccin on protein synthesis by a rabbit reticulocyte lysate is enhanced after preincubation of the toxins with GSH in the presence of a thiol:protein disulfide oxidoreductase purified from bovine liver. The same toxins, as well as the toxin from Viscum album, are reduced also by another thiol:protein disulfide oxidoreductase purified from rat liver cytosol. |
| Keywords: | Author to whom all correspondence should be addressed: Istituto di Patologia generale Via S Giacomo 14 I-40126 Bologna Italy |
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