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Monoclonal antibodies directed against the sugar sequence of lacto-N-fucopentaose III are obtained from mice immunized with human tumors |
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| Authors: | Manfred Brockhaus John L. Magnani Meenhard Herlyn Magdalena Blaszczyk Zenon Steplewski Hilary Koprowski Victor Ginsburg | |
| Affiliation: | 1. National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20205, U.S.A.;2. The Wistar Institute, Philadelphia, Pennsylvania 19104 U.S.A. | |
| Abstract: | Four hybridomas obtained from mice immunized with human adenocarcinomas of colon or stomach produce antibodies that bind specifically in solid-phase radioimmunoassay to the ceramide pentasaccharide that contains the lacto-N-fucopentaose III sequence of sugars. Binding of the antibodies to the glycolipid is inhibited by lacto-N-fucopentaose III,  | |
| Keywords: | To whom correspondence should be addressed: Building 4 Room 327 National Institutes of Health Bethesda Md. 20205. | |
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