VD缺乏相关疾病及其合理补充的临床意义

：众所周知，人体内维生素D水平与少年佝偻病和老年骨质疏松直接相关。最近大量流行病学证据还表明，维生素D（VD）缺乏是多种自身免疫性疾病，癌症，心血管疾病，抑郁症，老年痴呆症，感染性疾病，肌肉骨骼功能下降等的危险因素之一。另外，胰岛素抵抗，高血压和高胆固醇血症也与维生素D缺乏有关。因此，合理补充维生素D可以降低多种疾病风险，并对心血管疾病的风险有益。本文系根据已有的研究结论，阐述维生素D水平与多种临床疾病之间的关联，并对人体血清VD浓度合理监测及合理补充的临床意义做一综述。

A System Review of the Critical Role of Vitamin D in the Clinical Implications of Vitamin D Deficiency

As we all know, Vitamin D deficiency may lead to osteoporosis and muscle weakness, increasing the risk for osteoporotic fractures, the vitamin D level is directly related to juvenile rickets and osteoporosis in the elderly. However, a large number of epidemiological evidence show that lack of vitamin D （VD） is an important risk factors for a variety of diseases, including cancer, cardiovascular disease, depression, Alzheimer＇s disease, infectious disease, musculoskeletal function decline, etc. In contrast, vitamin D supplementation can reduce the risk of many diseases, a lot of patients with disease were beneficial from VD. In this study, we reviewed the existing research findings on the association between vitamin D levels and a variety of clinical disease, and consider the concentration of human serum Vitamin D monitoring and clinical significance.