新型的DNA金属化制作工艺

生物与微细加工技术的结合日益成为一种新趋势，DNA分子具有热力学上的稳定性、线性的分子结构及机械刚性等优点，可以作为制备纳米线的理想模板。通过DNA为模板的金属化，形成导电性好的金属纳米线和金属团簇的纳米结构，使得DNA分子作为纳米导线构筑纳米器件成为可能。在本文中，我们对几种具有代表性的DNA金属化工艺的原理进行了讨论，研究了其新型的制作工艺，通过进一步的自组装和自识别技术，金属化过的DNA就可以被用来构建电路，并作为后续的金属沉积模板，在构筑生物纳米器件的领域将有广阔的应用前景。

Novel fabrication processes for DNA metallization

The combination of biology and micro/nano fabrication technology is becoming a new trend, DNA molecules have many characteristics, such as good thermal stability, linear geometry structure and mechanical rigidity, which can be used as ideal templates for nanowire fabrication. By utilizing metallization technology, DNA can make up conductive metal nanowires and nanoclusters, which provides a possibility of constructing nano-devices by metallized DNA molecules. In this article, firstly, we introduce DNA metallization principles. Secondly, we discuss several novel DNA metallization processes, including whole DNA metallization, selective DNA metallization, ionic surface masking decreasing nonspecific DNA metallization and evaporation DNA metallization. Finally, by self-assembly and self-recognition techniques, metallized DNA can be used to build up electronic circuits and used as the metal deposition templates to construct bio-nano devices.