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The prevalence of Th17 cells in patients with gastric cancer |
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| Authors: | Zhang Bin Rong Guanghua Wei Huafeng Zhang Meng Bi Jianwei Ma Liye Xue Xuchao Wei Guo Liu Xiaokang Fang Guoen |
| Institution: | a Department of General Surgery, Changhai Hospital, The Second Military Medical University, No. 168, Changhai Road, Shanghai 200433, PR China b Department of Laboratory Medicine, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, PR China c International Joint Cancer Institute, The Second Military Medical University, Shanghai 200433, PR China d Department of Laboratory Medicine, The Second Artillary General Hospital, Beijing 100088, PR China |
| Abstract: | Th17 cells have emerged as an important mediator in inflammatory and autoimmune diseases. However, recent studies suggest a potential impact of Th17 cells on tumor. The current study was designed to investigate the possible involvement of Th17 cells in gastric cancer. Compared with healthy volunteers, patients with gastric cancer had a higher proportion of Th17 cells in peripheral blood. Notably, the increased prevalence of Th17 cells was associated with clinical stage. In addition, increased populations of Th17 cells were present in tumor-draining lymph nodes with advanced disease. Furthermore, the mRNA expression levels of Th17-related factors (IL-17, IL-23p19, and RORC) in tumor tissues and the serum concentrations of IL-17 and IL-23 cytokines were significantly increased in patients with advanced gastric cancer. The results indicate that Th17 cells may contribute to gastric cancer pathogenesis. |
| Keywords: | Th17 cells IL-17 IL-23 RORC Gastric cancer |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |