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Analysis of full and partial agonists binding to β2‐adrenergic receptor suggests a role of transmembrane helix V in agonist‐specific conformational changes |
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| Authors: | Vsevolod Katritch Kimberly A Reynolds Vadim Cherezov Michael A Hanson Christopher B Roth Mark Yeager Ruben Abagyan |
| Institution: | 1. Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA;2. Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA;3. Department of Molecular Physiology and Biological Physics, University of Virginia Health System, PO Box 800736, Charlottesville, VA 22908‐0736, USA |
| Abstract: | |
| Keywords: | adrenergic GPCR G‐protein agonist antagonist activation flexible docking binding energy |