核型多角体病毒侵染及其与宿主免疫系统互作的研究进展

核型多角体病毒(Nucleopolyhedrovirus,NPV)应用广泛,已被开发成微生物杀虫剂和用于重组蛋白表达等.NPV具有两种病毒颗粒:包埋型病毒粒子(occlusion-derived virus,ODV)和芽生型病毒粒子(budded virus,BV),两者的构成和组装存在差异.病毒包涵体在肠道中溶解后释...

Advance in the research of nucleopolyhedrovirus infection and its interaction with host immune system

Nucleopolyhedrovirus (NPV)has been widely used as a biological control agent and an expression system for recombinant proteins.There are two virion phenotypes, occlusion-derived virus (ODV)and the budded virus (BV), that are distinct in the composition and assembly during the infection cycle. The primary infection occurs when occlusion bodies (OBs)are disassembled to release ODV virions into lumen of the midgut. The progeny nucleocapsids are transported to the plasma membrane to generate BV phenotype. The BV virions may infect other tissues and cause secondary phase of infection. Insects possess efficient innate immune defenses to viral infection, whereas NPV has evolved various strategies to suppress or avoid host immune responses. The interaction processes between NPV and host immune system include immune signaling pathway, melanization and apoptosis. In this paper, we summarize recent studies on the interactions between Lepidopteran-specific nucleopolyhedrovirus and their insect hosts, mainly focus on the mechanisms of infection, and the interaction between NPV and host immune system.