Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. |
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Authors: | M F Bachmann G K?hler B Ecabert T W Mak M Kopf |
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Institution: | Basel Institute for Immunology, Switzerland. |
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Abstract: | Mice deficient for the expression of CTLA-4 develop a lethal lymphoproliferative syndrome and multiorgan inflammation leading to death at about 4 wk of age. Here we show that RAG2-deficient mice reconstituted with CTLA-4-deficient bone marrow do not develop a lymphoproliferative syndrome despite lymphocyte infiltration mainly into pericardium and liver. Moreover, RAG2-deficient mice reconstituted with a mixture of normal and CTLA-4-deficient bone marrow remain healthy and do not develop any disease. Thus, the lethal disease observed in CTLA-4-deficient mice is not T cell autonomous and can be prevented by factors produced by normal T cells. |
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