三种金属硫蛋白聚合体的疏水性相互作用研究

通过分子表面的计算考察了三类金属硫蛋白（大鼠金属硫蛋白亚型Ⅱ，兔肝金属硫蛋白亚型Ⅰ和Ⅱ）二聚体短聚体中组成单元之间的疏水性相互作用。计算结果表明二聚体和三聚体中各组成单元之间均可以形成较好的几何匹配。对于二聚体而言，单体和单体之间存在一定的疏水性相互作用，但作用力 三聚体中，单体和二聚体之间的疏水残基能通过好的空间匹配形成很强的疏水性相互作用。对于这三种金属硫蛋白，二聚体中单体和单体之间的疏水性相

STUDIES ON HYDROPHOBIC INTERACTIONS OF THREE KINDSOF METALLOTHIONEIN AGGREGATES

In this paper, the hydrophobic interaction between constituent units in dimers and trimers was studied by calculating the solvent-accessible surface areas. Three kinds of metallothioneins including MT-II from rat liver, MT-I and MT-II from rabbit were investigated. The total area of the binding interface for the dimers and trimers showed that all of them possess good steric complementarity. For three dimers, the hydrophobic interactions between two monomers were not very strong. But for three trimers, the hydrophobic interactions between the monomers and dimers were significant. Moreover, the hydrophobic effects for the MT-II trimer from rat liver and MT-II trimer from rabbit were clearly much stronger than that of the MT-I trimer from rabbit.