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Inhibition of the Na+/Ca2+ exchange in cardiac sarcolemmal vesicles by amiloride
Authors:P Debetto  M Floreani  F Carpenedo  S Luciani
Affiliation:1. Department of Material Engineering, Zhejiang Industry & Trade Vocational College, Wenzhou 325003, China;2. School of Mechanical and Electrical Engineering, Wenzhou University, Wenzhou 325035, China;3. School of Materials Science and Engineering, Xiangtan University, Xiangtan 411105, China;1. Department of Chemistry, Art & Science Faculty, Pamukkale University, Denizli, Turkey;2. Department of Photonics, Izmir Institute of Technology, 35430, Urla, Izmir, Turkey;3. Nanotechnology and Advanced Materials Laboratory, Electrical and Computer Engineering Department, University of the Peloponnese, 26334, Patras, Greece;1. Business School, Sichuan University, Chengdu 610065, China;2. State Key Laboratory of Hydraulics and Mountain River Engineering, Sichuan University, Chengdu 610065, China;3. Development Division, PetroChina Southwest Oil & Gasfield Company, Chengdu 610066, China
Abstract:
The pyrazine diuretic amiloride inhibits the Na+/Ca2+ exchange activity of cardiac sarcolemmal vesicles in a concentration-dependent way. A good relationship between the uptake of amiloride by the vesicles and the inhibition of the exchanger has been found. Kinetic analyses indicate that the inhibition of Na+/Ca2+ exchange activity by amiloride is non-competitively removed by Ca2+ and competitively overcome by an outwardly directed Na+ gradient.
Keywords:
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