Alteration of the regulatory properties of chicken liver fructose-1,6-bisphosphatase by treatment with aspirin. |
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Authors: | P F Han G Y Han H C McBay J Johnson |
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Institution: | Department of Pharmacology and Nutrition University of Southern California School of Medicine Los Angeles, CA 90033 USA |
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Abstract: | A number of agents were tested for their ability to enhance the p-hydroxylation of aniline using isolated hepatocytes as a model system. Although the observed stimulation or inhibition was not concentration dependent, various substrates for the hepatic mixed-function oxygenase (MFO) system (p-nitroanisole, 7-ethoxycoumarin, biphenyl, N,N′-dimethylaminoazobenzene, and benzphetamine) stimulated the hydroxylation at a concentration of 0.5 mm. This effect was not seen with all substrates. In general, aniline hydroxylation was not affected by the other agents tested (steroids, metabolic inhibitors and MFO inhibitors). However, enhancement was noticed with testosterone and progesterone at the lowest concentration (0.05 mm), with 2,6-dichloro-4-nitrophenol and salicylamide at 0.05 mm and 0.5 mm and with 7,8-benzoflavone at 5.0 mm. |
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