| I类整合子与产ESBLs肺炎克雷伯菌多重耐药关系的研究 |
| |
| 引用本文： | 郑宇琼,陈淑贞,姚芬,蔡应木,钱元恕,林少微.I类整合子与产ESBLs肺炎克雷伯菌多重耐药关系的研究[J].中国微生态学杂志,2009,21(2):116-117. |
| |
| 作者姓名： | 郑宇琼 陈淑贞 姚芬 蔡应木 钱元恕 林少微 |
| |
| 作者单位： | 1. 汕头大学医学院第一附属医院,广东,汕头,515041
2. 汕头大学医学院,广东,汕头,515041 |
| |
| 摘 要： | 目的了解产ESBLs肺炎克雷伯菌的整合子存在状况。方法用PCR方法扩增Ⅰ类整合酶基因，经电泳后检测扩增产物。结果72株产ESBLs肺炎克雷伯菌中检测出Ⅰ类整合子67株，检出率为93．0％，Ⅰ类整合子阳性菌对氨基糖苷类、喹诺酮类及头孢菌素类药物表现出较高的耐药，其多重耐药率明显高于Ⅰ类整合子阴性菌株（P〈0．05）。结论Ⅰ类整合子广泛地存在产ESBLs肺炎克雷伯菌中,Ⅰ类整合子对细菌多重耐药性的产生和传播起着重要作用。
|
| 关 键 词： | 肺炎克雷伯菌 ESBLs 整合子 多重耐药 |
Identification of classⅠintegrons and multidrug resistance in ESBLs-producing Klebsiella pneumonia |
| |
| ZHENG Yu-qiong,CHEN Shu-zhen,YAO Fen,CAI Ying-mu,QIAN Yuan-shu,LIN Shao-wei.Identification of classⅠintegrons and multidrug resistance in ESBLs-producing Klebsiella pneumonia[J].Chinese Journal of Microecology,2009,21(2):116-117. |
| |
| Authors: | ZHENG Yu-qiong CHEN Shu-zhen YAO Fen CAI Ying-mu QIAN Yuan-shu LIN Shao-wei |
| |
| Institution: | ZHENG Yu-qiong, CHEN Shu-zhen ,YAO Fen, CAI Ying-mu, QIAN Yuan-shu, LIN Shao-wei ( 1. Department of Clinical Laboratory, First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China ;2. First Affiliated Hospital of Shantou University Medical College ,Shantou 515041, China) |
| |
| Abstract: | Objective To investigate class Ⅰ integrons in ESBLs-producing Klebsiella pneumonia. Method Class Ⅰ integron gene was analyzed by PCR. Result Class Ⅰ integron gene was found in 93.0% of 72 strains of ESBLs-producing Klebsiella pneumonia. The positive strains of class Ⅰ integrons showed higher multidrug resistance to aminoglycosides and/or fluoroquinolones and/or cephalospofins than the negative strains of class Ⅰ integrons （ P 〈 0. 05 ）. Conclusion Class Ⅰ integrons were prevalent in ESBLs-produeing Klebsielta pneumonia and played an important role in the development and dissemination of muhidrug resistance. |
| |
| Keywords: | ESBLs |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
