抗HCV药物筛选系统研究进展

丙型肝炎病毒(Hepatitis C virus,HCV)感染的持久性引发慢性肝病疾病,并可能发展成为肝硬化和肝癌。目前对HCV的治疗不能达到理想的治疗效果,所以开发新型抗HCV药物迫在眉睫。抗HCV药物筛选的细胞模型,如复制子系统、假病毒系统、细胞培养系统,动物模型,如黑猩猩、uPA-SCID小鼠等,取得了快速的进展,并推动丙型肝炎的研究和抗HCV药物的发现。

Progress in evaluation systems of anti-HCV drugs

Hepatitis C virus（HCV） causes persistent infection and induces serious chronic hepatitis,liver cirrhosis,and ultimately hepatocellular.The current therapyies can not receive satisfactory results,so the development of new anti-HCV drugs is important.The cell models for drug screening,such as replicon system,HCV pseudotype particles,cell culture systems,and the animal model such as chimpanzees and uPA-SCID mice,have made rapid progress,these progress will propel HCV research and the anti-HCV drug discovery.