| mRNA出核转运及其偶联网络 |
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| 引用本文： | 迟斌凯,朱长兰,王庆亮,王兰甜,程红. mRNA出核转运及其偶联网络[J]. 生命科学, 2010, 0(7): 703-709 |
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| 作者姓名： | 迟斌凯 朱长兰 王庆亮 王兰甜 程红 |
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| 作者单位： | 中国科学院上海生命科学研究院生物化学与细胞生物学研究所,中国科学院分子生物学国家重点实验室,上海200031 |
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| 基金项目： | 中国科学院“百人计划”（2008OHTP03）; 上海市浦江人才项目（09PJ1411300）; 国家自然科学基金面上项目（30970583） |
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| 摘 要： | 真核细胞中,编码蛋白质基因的表达是一个复杂的、分步骤进行的过程,这个过程从转录和新生pre-mRNA的核内加工开始,经过正确加工的成熟mRNA从加工位点释放,出核转运后在细胞质内翻译成蛋白质。mRNA出核转运是基因表达中的关键步骤,由进化上高度保守的特定蛋白质介导完成。mRNA出核与转录和mRNA加工步骤密切偶联,这样的偶联可以提高基因表达的有效性和准确性。
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| 关 键 词： | mRNA出核 偶联 基因表达 TREX |
mRNA export and its coupling in gene expression |
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| CHI Bin-kai,ZHU Chang-lan,WANG Qing-liang,WANG Lan-tian,CHENG Hong. mRNA export and its coupling in gene expression[J]. Chinese Bulletin of Life Sciences, 2010, 0(7): 703-709 |
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| Authors: | CHI Bin-kai ZHU Chang-lan WANG Qing-liang WANG Lan-tian CHENG Hong |
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| Affiliation: | (State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China) |
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| Abstract: | In eukaryotes,the expression of protein-coding genes is a complex stepwise process,which begins with transcription and processing of nascent transcripts in the nucleus. Upon maturation,the mature mRNAs are then released from the processing site and exported into the cytoplasm for translation into proteins. mRNA export is a critical step in gene expression,which involves a specific cellular machinery that is highly conserved from yeast to humans. mRNA export is coupled to transcription and mRNA processing steps,and this extensive coupling may enhance the efficiency and fidelity of gene expression. |
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| Keywords: | mRNA export coupling gene expression TREX |
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