| SDF-1/CXCR4轴在骨再生修复中的研究进展 |
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| 引用本文： | 廖新根,殷明,李士勇,吴梨华,刘哲,付明福.SDF-1/CXCR4轴在骨再生修复中的研究进展[J].生命科学,2010(10):1069-1073. |
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| 作者姓名： | 廖新根 殷明 李士勇 吴梨华 刘哲 付明福 |
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| 作者单位： | [1]南昌大学研究生院医学部,南昌330006 [2]南昌大学第二附属医院骨科,南昌330006 [3]南昌大学第二附属医院分子医学中心,南昌330006 |
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| 摘 要： | 基质细胞衍生因子-1(stromal cell-derived factor-1,SDF-1)及其受体CXCR4构成SDF-1/CXCR4轴系统具有许多重要的生物学特性和功能。近年来随着该领域的研究不断深入,越来越多的发现表明,SDF-1/CXCR4轴系统在组织损伤及修复中起着重要作用,其在骨组织再生修复中的作用也日益受到关注。该文主要对SDF-1/CXCR4轴系统的生物学特性及其在骨再生修复中的作用进行综述。
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| 关 键 词： | 基质细胞衍生因子-1 SDF-1/CXCR4轴系统 生物学特性 骨再生修复 |
Progress of SDF-1/CXCR4 axis in bone regeneration |
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| LIAO Xin-gen,YIN Ming,LI Shi-yong,WU Li-hua,LIU Zhe,FU Ming-fu.Progress of SDF-1/CXCR4 axis in bone regeneration[J].Chinese Bulletin of Life Sciences,2010(10):1069-1073. |
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| Authors: | LIAO Xin-gen YIN Ming LI Shi-yong WU Li-hua LIU Zhe FU Ming-fu |
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| Institution: | 1 Graduate School of Medicine, Nanchang University, Nanchang 330006, China; 2 Second Affiliated Hospital ofNanchang University, Nanchang 330006, China; 3 Center for Molecular Medicine, Second Affiliated Hospital ofNanchang University, Nanchang 330006, China) |
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| Abstract: | The SDF-1/CXCR4 axis system constituted by stromal cell-derived factor -1 （SDF-1） and its receptor CXCR4 has many important biological characteristics and functions. With deepening research in the field in recent years, the growing number of findings suggest that the SDF-1/CXCR4 axis system plays an important role in regeneration and repair of tissue injury , what’s more, the role of SDF-1/CXCR4 axis system in the regeneration of bone tissue are also increasingly concerned. This article reviews the biological characteristics of the SDF-1/CXCR4 axis system and its role in bone regeneration and repair. |
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| Keywords: | stromal cell-derived factor-1 SDF-1/CXCR4 axis system biological characteristics bone regenerationand repair |
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